Article
Rare PDCD11 variations are not associated with risk of schizophrenia in Japan.
Psychiatry and clinical neurosciences - 1 Nov 2017
Hoya Satoshi, Watanabe Yuichiro, Hishimoto Akitoyo, Nunokawa Ayako, Kaneko Naoshi, Muratake Tatsuyuki, Shinmyo Naofumi, Otsuka Ikuo, Okuda Shujiro, Inoue Emiko, Igeta Hirofumi, Shibuya Masako, Egawa Jun, Orime Naoki, Sora Ichiro, Someya Toshiyuki
Abstract excerpt
AIM: Rare gene variations are thought to confer substantial risk for schizophrenia. We performed a three-stage study to identify rare variations that have a strong impact on the risk of developing schizophrenia. METHODS: In the first stage, we prioritized rare missense variations using whole-exome sequencing (WES) data from three families, consisting of a proband, an affected sibling, and parents. In the second...
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