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Rare nonsynonymous germline and mosaic de novo variants in Japanese patients with schizophrenia.

Psychiatry and clinical neurosciences - 1 Jan 2025

Watanabe Yuichiro, Nishioka Masaki, Morikawa Ryo, Takano-Isozaki Satoko, Igeta Hirofumi, Mori Kanako, Kato Tadafumi, Someya Toshiyuki

Abstract excerpt

AIM: Whole-exome sequencing (WES) studies have revealed that germline de novo variants (gDNVs) contribute to the genetic etiology of schizophrenia. However, the contribution of mosaic DNVs (mDNVs) to the risk of schizophrenia remains to be elucidated. In the present study, we systematically investigated the gDNVs and mDMVs that contribute to the genetic etiology of schizophrenia in a Japanese population. METHODS:...

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PMID: 39439118
DOI: 10.1111/pcn.13758

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