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Article

Whole-exome sequencing in a family with a monozygotic twin pair concordant for schizophrenia and a follow-up case-control study of identified de-novo variants.

Psychiatric genetics - 1 Apr 2020

Hoya Satoshi, Watanabe Yuichiro, Nunokawa Ayako, Otsuka Ikuo, Shibuya Masako, Igeta Hirofumi, Hishimoto Akitoyo, Someya Toshiyuki

Abstract excerpt

Whole-exome sequencing (WES) studies have shown that de-novo variants contribute to the genetic etiology of schizophrenia. WES studies of families with a monozygotic twin pair concordant or discordant for a disease may be fruitful for identifying de-novo pathogenic variants. Here, we performed WES in six individuals from one family (affected monozygotic twins, their unaffected parents, and two siblings) and...

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PMID: 32106127
DOI: 10.1097/YPG.0000000000000250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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