Article
Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.
Psychiatry research - 30 Jan 2016
Watanabe Yuichiro, Nunokawa Ayako, Shibuya Masako, Ikeda Masashi, Hishimoto Akitoyo, Kondo Kenji, Egawa Jun, Kaneko Naoshi, Muratake Tatsuyuki, Saito Takeo, Okazaki Satoshi, Shimasaki Ayu, Igeta Hirofumi, Inoue Emiko, Hoya Satoshi, Sugai Takuro, Sora Ichiro, Iwata Nakao, Someya Toshiyuki
Abstract excerpt
Rare inherited variations in multiplex families with schizophrenia are suggested to play a role in the genetic etiology of schizophrenia. To further investigate the role of rare inherited variations, we performed whole-exome sequencing (WES) in three families, each with two affected siblings. We also performed a three-stage follow-up case-control study in a Japanese population with a total of 2617 patients and...
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