Article
Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia.
Journal of genetics and genomics = Yi chuan xue bao - 20 Jun 2017
Tang Jinsong, Fan Yu, Li Hong, Xiang Qun, Zhang Deng-Feng, Li Zongchang, He Ying, Liao Yanhui, Wang Ya, He Fan, Zhang Fengyu, Shugart Yin Yao, Liu Chunyu, Tang Yanqing, Chan Raymond C K, Wang Chuan-Yue, Yao Yong-Gang, Chen Xiaogang
Abstract excerpt
Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive. We implemented whole-genome sequencing (WGS) analysis of 8 families with monozygotic (MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations (DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs (including one splicing site)...
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