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Article

Exome sequencing supports a de novo mutational paradigm for schizophrenia.

Nature genetics - 7 Aug 2011

Xu Bin, Roos J Louw, Dexheimer Phillip, Boone Braden, Plummer Brooks, Levy Shawn, Gogos Joseph A, Karayiorgou Maria

Abstract excerpt

Despite its high heritability, a large fraction of individuals with schizophrenia do not have a family history of the disease (sporadic cases). Here we examined the possibility that rare de novo protein-altering mutations contribute to the genetic component of schizophrenia by sequencing the exomes of 53 sporadic cases, 22 unaffected controls and their parents. We identified 40 de novo mutations in 27 cases...

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Share to Chromosomes, Human, Pair 22
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Membrane Glycoproteins

Share to Platelet Glycoprotein GPIb-IX Complex

Share to Schizophrenia

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 21822266
DOI: 10.1038/ng.902
PMCID: PMC3196550

Genes

DGCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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