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Article

Environmental change drives accelerated adaptation through stimulated copy number variation.

PLoS biology - 1 Jun 2017

Hull Ryan M, Cruz Cristina, Jack Carmen V, Houseley Jonathan

Abstract excerpt

Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human disorders, particularly cancer, in which CNV promotes both tumorigenesis and chemotherapy resistance. CNVs are considered random mutations but often arise through replication defects; transcription can interfere with replication fork progression and stability, leading to increased mutation rates at highly transcribed...

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PMID: 28654659
DOI: 10.1371/journal.pbio.2001333
PMCID: PMC5486974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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