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Article

Mutational bias shaping fly copy number variation: implications for genome evolution.

Trends in genetics : TIG - 1 Jun 2010

Cardoso-Moreira Margarida M, Long Manyuan

Abstract excerpt

Copy number variants (CNVs) underlie several genomic disorders and are a major source of genetic innovation. Consequently, any bias affecting their placement in the genome will impact our understanding of human disease and genome evolution. Here we report a mutational bias affecting CNVs that generates different probabilities of duplication and deletion across the genome in association with DNA replication time....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20416969
DOI: 10.1016/j.tig.2010.03.002
PMCID: PMC2878862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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