Article

Stimulation of adaptive gene amplification by origin firing under replication fork constraint

2021-03-04

Abstract excerpt

Adaptive mutations can cause drug resistance in cancers and pathogens, and increase the tolerance of agricultural pests and diseases to chemical treatment. When and how adaptive mutations form is often hard to discern, but we have shown that adaptive copy number amplification of the copper resistance gene CUP1 occurs in response to environmental copper due to CUP1 transcriptional activation. Here we dissect the...

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Literature Corpus work: f06004a1-2b5c-53bd-b7aa-ab74204e6f3d
DOI: 10.1101/2021.03.04.433911

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