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Article

The effect of spontaneous mutations on CUP1 copy number and copper tolerance in Saccharomyces cerevisiae.

Biology letters - 6 May 2026

Sohoni Rohan, Schatz Gillian G, Sharp Nathaniel

Abstract excerpt

Genomic regions containing tandem duplications may be subject to particularly high rates of copy number mutations due to recombinational repair of DNA damage. Consequently, changes in copy number may be among the most accessible beneficial mutations during evolution in a new environment. In the budding yeast Saccharomyces cerevisiae, the gene CUP1 occurs in multiple tandem copies and encodes a metallothionein...

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PMID: 42087439
DOI: 10.1098/rsbl.2026.0090

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