Article
Polygenic risk for schizophrenia and neurocognitive performance in patients with schizophrenia.
Genes, brain, and behavior - 1 Jan 2018
Wang S-H, Hsiao P-C, Yeh L-L, Liu C-M, Liu C-C, Hwang T-J, Hsieh M H, Chien Y-L, Lin Y-T, Chandler S D, Faraone S V, Laird N, Neale B, McCarroll S A, Glatt S J, Tsuang M T, Hwu H-G, Chen W J
Abstract excerpt
Both neurocognitive deficits and schizophrenia are highly heritable. Genetic overlap between neurocognitive deficits and schizophrenia has been observed in both the general population and in the clinical samples. This study aimed to examine if the polygenic architecture of susceptibility to schizophrenia modified neurocognitive performance in schizophrenia patients. Schizophrenia polygenic risk scores (PRSs) were...
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