Article
Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls.
Translational psychiatry - 12 Apr 2018
Shafee Rebecca, Nanda Pranav, Padmanabhan Jaya L, Tandon Neeraj, Alliey-Rodriguez Ney, Kalapurakkel Sreeja, Weiner Daniel J, Gur Raquel E, Keefe Richard S E, Hill Scot K, Bishop Jeffrey R, Clementz Brett A, Tamminga Carol A, Gershon Elliot S, Pearlson Godfrey D, Keshavan Matcheri S, Sweeney John A, McCarroll Steven A, Robinson Elise B
Abstract excerpt
Psychotic disorders including schizophrenia are commonly accompanied by cognitive deficits. Recent studies have reported negative genetic correlations between schizophrenia and indicators of cognitive ability such as general intelligence and processing speed. Here we compare the effect of polygenetic risk for schizophrenia (PRSSCZ) on measures that differ in their relationships with psychosis onset: a measure of...
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