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Article

A functional variant in ERAP1 predisposes to multiple sclerosis.

PloS one - 1 Jan 2012

Guerini Franca Rosa, Cagliani Rachele, Forni Diego, Agliardi Cristina, Caputo Domenico, Cassinotti Andrea, Galimberti Daniela, Fenoglio Chiara, Biasin Mara, Asselta Rosanna, Scarpini Elio, Comi Giacomo P, Bresolin Nereo, Clerici Mario, Sironi Manuela

Abstract excerpt

The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune disorder, Crohn's disease (CD). We analysed rs30187 in 572 Italian patients with CD and in 517 subjects suffering...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aminopeptidases
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Share to Genetic Predisposition to Disease
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Share to Minor Histocompatibility Antigens
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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 22253828
DOI: 10.1371/journal.pone.0029931
PMCID: PMC3257233

Genes

ERAP1
ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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