AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

doi:10.1038/ncb3563

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Article

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Nature cell biology - 1 Jul 2017

Zhou Fengbiao, Liu Yi, Rohde Christian, Pauli Cornelius, Gerloff Dennis, Köhn Marcel, Misiak Danny, Bäumer Nicole, Cui Chunhong, Göllner Stefanie, Oellerich Thomas, Serve Hubert, Garcia-Cuellar Maria-Paz, Slany Robert, Maciejewski Jaroslaw P, Przychodzen Bartlomiej, Seliger Barbara, Klein Hans-Ulrich, Bartenhagen Christoph, Berdel Wolfgang E, Dugas Martin, Taketo Makoto Mark, Farouq Daneyal, Schwartz Schraga, Regev Aviv, Hébert Josée, Sauvageau Guy, Pabst Caroline, Hüttelmaier Stefan, Müller-Tidow Carsten

Abstract excerpt

Leukaemogenesis requires enhanced self-renewal, which is induced by oncogenes. The underlying molecular mechanisms remain incompletely understood. Here, we identified C/D box snoRNAs and rRNA 2'-O-methylation as critical determinants of leukaemic stem cell activity. Leukaemogenesis by AML1-ETO required expression of the groucho-related amino-terminal enhancer of split (AES). AES functioned by inducing snoRNA/RNP...

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PMID: 28650479
DOI: 10.1038/ncb3563

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