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Article

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.

PLoS genetics - 1 Dec 2014

Gerby Bastien, Tremblay Cedric S, Tremblay Mathieu, Rojas-Sutterlin Shanti, Herblot Sabine, Hébert Josée, Sauvageau Guy, Lemieux Sébastien, Lécuyer Eric, Veiga Diogo F T, Hoang Trang

Abstract excerpt

The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to define the critical initiating events in this d...

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Topics

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LIM Domain Proteins

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Share to Thymocytes

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 25522233
DOI: 10.1371/journal.pgen.1004768
PMCID: PMC4270438

Genes

LMO1
NOTCH1
LYL1
LMO2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25522233-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.PMID 25522233Read ↗

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The <i>Lmo2</i> Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-RenewalSemantic proximity Read ↗

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