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A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

15 Jul 2017

Abstract excerpt

cells promotes a preleukemic state with enhanced self-renewal and dysregulated differentiation. The DNA binding domain of FOXO1 is essential for these functions. FOXO1 activates a stem cell molecular signature that is also present in AE preleukemia cells and preserved in t(8;21) patient samples. Genome-wide binding studies show that AE and FOXO1 share the majority of their binding sites, whereby FOXO1 binds to...

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PMID: 28710059
DOI: 10.1182/blood-2016-11-750976

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