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Article

AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein

19 Jan 2011

Abstract excerpt

The most frequent translocation t(8;21) in acute myeloid leukemia (AML) generates the chimeric AML1/ETO protein, which blocks differentiation and induces self-renewal in hematopoietic progenitor cells. The underlying mechanisms mediating AML1/ETO-induced self-renewal are largely unknown. Using expression microarray analysis, we identified the Groucho-related amino-terminal enhancer of split (AES) as a...

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PMID: 21245488
DOI: 10.1182/blood-2009-09-242545

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AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES proteinPMID 21245488Read ↗

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