Article
An efficient Screening System in Yeast to Select a Hyperactive piggyBac Transposase for Mammalian Applications.
International journal of molecular sciences - 26 Apr 2020
Wen Wen, Song Shanshan, Han Yuchun, Chen Haibin, Liu Xiangzhen, Qian Qijun
Abstract excerpt
As non-viral transgenic vectors, the piggyBac transposon system represents an attractive tool for gene delivery to achieve a long-term gene expression in immunotherapy applications due to its large cargo capacity, its lack of a trace of transposon and of genotoxic potential, and its highly engineered structure. However, further improvements in transpose activity are required for industrialization and clinical...
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