Comorbidities in the diseasome are more apparent than real: What Bayesian filtering reveals about the comorbidities of depression

Abstract excerpt

Comorbidity patterns have become a major source of information to explore shared mechanisms of pathogenesis between disorders. In hypothesis-free exploration of comorbid conditions, disease-disease networks are usually identified by pairwise methods. However, interpretation of the results is hindered by several confounders. In particular a very large number of pairwise associations can arise indirectly through...

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