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Article

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies.

The Journal of biological chemistry - 30 May 2014

Figaj Donata, Gieldon Artur, Polit Agnieszka, Sobiecka-Szkatula Anna, Koper Tomasz, Denkiewicz Milena, Banecki Bogdan, Lesner Adam, Ciarkowski Jerzy, Lipinska Barbara, Skorko-Glonek Joanna

Abstract excerpt

Bacterial HtrAs are serine proteases engaged in extracytoplasmic protein quality control and are required for the virulence of several pathogenic species. The proteolytic activity of HtrA (DegP) from Escherichia coli, a model prokaryotic HtrA, is stimulated by stressful conditions; the regulation of this process is mediated by the LA, LD, L1, L2, and L3 loops. The precise mechanism of action of the LA loop is not...

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Identifiers

PMID: 24737328
DOI: 10.1074/jbc.M113.532895
PMCID: PMC4140941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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