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Article

Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort.

BMC genomics - 30 May 2017

Cong Wang, Meng Xianglian, Li Jin, Zhang Qiushi, Chen Feng, Liu Wenjie, Wang Ying, Cheng Sipu, Yao Xiaohui, Yan Jingwen, Kim Sungeun, Saykin Andrew J, Liang Hong, Shen Li

Abstract excerpt

BACKGROUND: The cerebrospinal fluid (CSF) levels of total tau (t-tau) and Aβ1-42 are potential early diagnostic markers for probable Alzheimer's disease (AD). The influence of genetic variation on these CSF biomarkers has been investigated in candidate or genome-wide association studies (GWAS). However, the investigation of statistically modest associations in GWAS in the context of biological networks is still...

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Identifiers

PMID: 28558704
DOI: 10.1186/s12864-017-3798-z
PMCID: PMC5450240

Genes

AKAP5
BCL3
CALM1
CASP8
CFLAR
DLG4
NGFR
PARP1
PPA1
RHOA
SMAD1
SUMO1

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