The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects.

doi:10.1111/bcp.13237

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Article

The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects.

British journal of clinical pharmacology - 1 Jul 2017

Stage Claus, Jürgens Gesche, Guski Louise Schow, Thomsen Ragnar, Bjerre Ditte, Ferrero-Miliani Laura, Lyauk Yassine Kamal, Rasmussen Henrik Berg, Dalhoff Kim

Abstract excerpt

AIMS: This study investigated the influence of CES1 variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate. METHODS: CES1 genotype was obtained from 200 healthy Danish Caucasian volunteers. Based on the genotype, 44 (19 males and 25 females) were invited to participate in an open,...

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Identifiers

PMID: 28087982
DOI: 10.1111/bcp.13237
PMCID: PMC5465325

Genes

CES1

Variants

rs71647871

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