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Article

Down syndrome, RASopathies, and other rare syndromes.

Seminars in hematology - 1 Apr 2017

Kratz Christian P, Izraeli Shai

Abstract excerpt

In this article we discuss the occurrence of myeloid neoplasms in patients with a range of syndromes that are due to germline defects of the RAS signaling pathway and in patients with trisomy 21. Both RAS mutations and trisomy 21 are common somatic events contributing to leukemogenis. Thus, the increased leukemia risk observed in children affected by these conditions is biologically highly plausible. Children...

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Identifiers

PMID: 28637616
DOI: 10.1053/j.seminhematol.2017.04.008

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