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The role of chromosome 21 in hematology and oncology

15 Mar 2010

Abstract excerpt

Newborns and children with Down syndrome (DS) often present with congenital transient leukemia and have an increased risk of acute myeloid leukemia and acute lymphoblastic leukemia. Thus, constitutional trisomy 21 represents an excellent model to study the origin and progression of leukemia. However, trisomy 21 can also occur as a somatic chromosome aberration leading to sporadic leukemia. During the 50 years,...

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PMID: 20232485
DOI: 10.1002/gcc.20764

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