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Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

20 May 2020

Abstract excerpt

Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. Gain of chromosome 21 is a frequently occurring aberration in several types of acute leukemia and...

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PMID: 32433508
DOI: 10.1038/s41375-020-0854-5

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