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Article

Overcoming evolved resistance to population-suppressing homing-based gene drives.

Scientific reports - 19 Jun 2017

Marshall John M, Buchman Anna, Sánchez C Héctor M, Akbari Omar S

Abstract excerpt

The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness advantage over functional, population-suppressing homing alleles. To explore this concern, we...

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Identifiers

PMID: 28630470
DOI: 10.1038/s41598-017-02744-7
PMCID: PMC5476637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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