Article
The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome.
Leukemia - 1 Sept 2026
Boucher Austin C, Rosikiewicz Wojciech, Cotton Anitria, Broadhurst Amber L, Ling Te, Vadlamudi Rishika, Bremm Melanie, Schmell Anna-Lena, Konada Lahiri, Niederkorn Madeline, Murray Josiah D, Li Yichao, Narina Shilpa, Inglott Sarah, Roy Anindita, Ancliff Philip, Tirtakusuma Ricky, Ma Jing, Walsh Michael P, Klco Jeffery M, Thomas Paul G, Wang Yiwen, Tsirigos Aristotelis, Cheng Yong, Xu Beisi, Ma Xiaotu, Meshinchi Soheil, Wagenblast Elvin, Pruett-Miller Shondra M, Rao Sridhar, Wu Gang, Olufadi Yunusa, Kang Guolian, Tothova Zuzana, Taub Jeffrey W, Ge Yubin, Vyas Paresh, Klusmann Jan-Henning, Crispino John D
Abstract excerpt
Children with Down syndrome (DS) frequently develop transient abnormal myelopoiesis that can evolve to the myeloid leukemia of DS (ML-DS). TAM spontaneously resolves in most cases but progresses to ML-DS with additional mutations, most commonly in the cohesin complex. However, the mechanisms by which these alterations promote leukemia are unknown. We leveraged the RAD21-mutant CMY cell line and RAD21-corrected...
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