Article
Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR.
EBioMedicine - 1 Jul 2017
Watanabe Masaru, Kawaguchi Tomoya, Isa Shun-Ichi, Ando Masahiko, Tamiya Akihiro, Kubo Akihito, Saka Hideo, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kawashima Osamu, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Watanabe Katsuya, Matsumura Akihide, Koh Yasuhiro
Abstract excerpt
Epidermal growth factor receptor (EGFR) mutations have been used as the strongest predictor of effectiveness of treatment with EGFR tyrosine kinase inhibitors (TKIs). Three most common EGFR mutations (L858R, exon 19 deletion, and T790M) are known to be major selection markers for EGFR-TKIs therapy. Here, we developed a multiplex picodroplet digital PCR (ddPCR) assay to detect 3 common EGFR mutations in 1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.