Plasma epidermal growth factor receptor mutation testing with a chip-based digital PCR system in patients with advanced non-small cell lung cancer.

doi:10.1016/j.lungcan.2017.02.001

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Plasma epidermal growth factor receptor mutation testing with a chip-based digital PCR system in patients with advanced non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2017

Kasahara Norimitsu, Kenmotsu Hirotsugu, Serizawa Masakuni, Umehara Rina, Ono Akira, Hisamatsu Yasushi, Wakuda Kazushige, Omori Shota, Nakashima Kazuhisa, Taira Tetsuhiko, Naito Tateaki, Murakami Haruyasu, Koh Yasuhiro, Mori Keita, Endo Masahiro, Nakajima Takashi, Yamada Masanobu, Kusuhara Masatoshi, Takahashi Toshiaki

Abstract excerpt

OBJECTIVES: Epidermal growth factor receptor (EGFR) mutation testing is a companion diagnostic to determine eligibility for treatment with EGFR tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC). Recently, plasma-based EGFR testing by digital polymerase chain reaction (dPCR), which enables accurate quantification of target DNA, has shown promise as a minimally invasive diagnostic. Here,...

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PMID: 28285688
DOI: 10.1016/j.lungcan.2017.02.001

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EGFR

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