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Article

Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations.

PloS one - 1 Jan 2016

Zonta Eleonora, Garlan Fanny, Pécuchet Nicolas, Perez-Toralla Karla, Caen Ouriel, Milbury Coren, Didelot Audrey, Fabre Elizabeth, Blons Hélène, Laurent-Puig Pierre, Taly Valérie

Abstract excerpt

In cancer research, the accuracy of the technology used for biomarkers detection is remarkably important. In this context, digital PCR represents a highly sensitive and reproducible method that could serve as an appropriate tool for tumor mutational status analysis. In particular, droplet-based digital PCR approaches have been developed for detection of tumor-specific mutated alleles within plasmatic circulating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27416070
DOI: 10.1371/journal.pone.0159094
PMCID: PMC4945036

Genes

EGFR
KRAS

Variants

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