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High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study

2025-11-07

Abstract excerpt

<h4>Backgrounds</h4> Next-generation sequencing (NGS) and droplet digital PCR (ddPCR) are both established methods for detecting EGFR mutations in non-small cell lung cancer (NSCLC). However, comprehensive validation of their concordance in mutation detection and variant allele frequency (VAF) quantification across heterogeneous sample types remains limited. Inconsistent results from different sample types (e.g.,...

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Literature Corpus work
5596b806-0da1-54bd-9a90-4a55735ef4e8
DOI
10.1101/2025.11.05.686693
Open publication

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High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort StudyDOI 10.1101/2025.11.05.686693
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