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Article

H3 K27M mutations are extremely rare in posterior fossa group A ependymoma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Jul 2017

Ryall Scott, Guzman Miguel, Elbabaa Samer K, Luu Betty, Mack Stephen C, Zapotocky Michal, Taylor Michael D, Hawkins Cynthia, Ramaswamy Vijay

Abstract excerpt

BACKGROUND: Mutations in the tail of histone H3 (K27M) are frequently found in pediatric midline high-grade glioma's but have rarely been reported in other malignancies. Recently, recurrent somatic nucleotide variants in histone H3 (H3 K27M) have been reported in group A posterior fossa ependymoma (EPN_PFA), an entity previously described to have no recurrent mutations. However, the true incidence of H3 K27M...

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PMID: 28623522
DOI: 10.1007/s00381-017-3481-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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