Article
H3 K27M mutations are extremely rare in posterior fossa group A ependymoma.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Jul 2017
Ryall Scott, Guzman Miguel, Elbabaa Samer K, Luu Betty, Mack Stephen C, Zapotocky Michal, Taylor Michael D, Hawkins Cynthia, Ramaswamy Vijay
Abstract excerpt
BACKGROUND: Mutations in the tail of histone H3 (K27M) are frequently found in pediatric midline high-grade glioma's but have rarely been reported in other malignancies. Recently, recurrent somatic nucleotide variants in histone H3 (H3 K27M) have been reported in group A posterior fossa ependymoma (EPN_PFA), an entity previously described to have no recurrent mutations. However, the true incidence of H3 K27M...
Topics
- Brain Neoplasms
- Child
- Ependymoma
- Histones
- Humans
- Lysine
- Magnetic Resonance Imaging
- Male
- Methionine
- Mutation