Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis

14 Sept 2022

Abstract excerpt

Posterior fossa group A ependymomas (EPN_PFA) are characterized by a loss of H3 K27 trimethylation due to either EZHIP overexpression or H3 p.K27M mutation, similar to H3 K27-altered diffuse midline gliomas (DMG), but in reverse proportions. Very little data is available in the literature concerning H3 K27M-mutant EPN_PFA. Here, we retrospectively studied a series of nine pediatric tumors initially diagnosed as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Vascular Malformations Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36104744
DOI: 10.1186/s40478-022-01442-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysisPMID 36104744Read ↗

EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymomaSemantic proximity Read ↗

Posterior fossa ependymoma harboring H3K27M mutation: A rare case report with clinical follow-up and diagnostic challenges.Semantic proximity Read ↗

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.Semantic proximity Read ↗

Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial locationSemantic proximity Read ↗

H3 K27M mutations are extremely rare in posterior fossa group A ependymoma.Semantic proximity Read ↗

EZH2 inhibitory protein (EZHIP/Cxorf67) expression correlates strongly with H3K27me3 loss in posterior fossa ependymomas and is mutually exclusive with H3K27M mutations.Semantic proximity Read ↗

Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG.Semantic proximity Read ↗

cIMPACT ‐ NOW update 11: Proposal on adaptation of diagnostic criteria for IDH ‐ and H3 ‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumorsSemantic proximity Read ↗

H3 K27M-mutant gliomas in adults vs. children share similar histological features and adverse prognosis.Semantic proximity Read ↗

A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation.Semantic proximity Read ↗

EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymomaSemantic proximity Read ↗

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.