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Posterior fossa ependymoma harboring H3K27M mutation: A rare case report with clinical follow-up and diagnostic challenges.

Clinical neuropathology - 1 Jan 2026

Das Sumanta, Charan Bheru Dan, Ahlawat Sunita, Gupta Rakesh Kumar, Shaikh Salman, Sharma Noopur, Karanth Suman S, Patir Rana

Abstract excerpt

Posterior fossa ependymomas may be classified based on H3 p.K28Me3 (also called as H3K27Me3 or K27Me3) expression status, with group A characterized by loss of K27Me3 expression. We present a rare case of posterior fossa ependymoma with H3K27M mutation, typically associated with diffuse midline gliomas. A 5-year-old child presented with headache and vomiting. Magnetic resonance imaging (MRI) revealed a 4th...

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Identifiers

PMID: 41553163
DOI: 10.5414/NP301708

Genes

EZHIP
GFAP
OLIG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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