Article
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
Acta neuropathologica - 1 Aug 2018
Pajtler Kristian W, Wen Ji, Sill Martin, Lin Tong, Orisme Wilda, Tang Bo, Hübner Jens-Martin, Ramaswamy Vijay, Jia Sujuan, Dalton James D, Haupfear Kelly, Rogers Hazel A, Punchihewa Chandanamali, Lee Ryan, Easton John, Wu Gang, Ritzmann Timothy A, Chapman Rebecca, Chavez Lukas, Boop Fredrick A, Klimo Paul, Sabin Noah D, Ogg Robert, Mack Stephen C, Freibaum Brian D, Kim Hong Joo, Witt Hendrik, Jones David T W, Vo Baohan, Gajjar Amar, Pounds Stan, Onar-Thomas Arzu, Roussel Martine F, Zhang Jinghui, Taylor J Paul, Merchant Thomas E, Grundy Richard, Tatevossian Ruth G, Taylor Michael D, Pfister Stefan M, Korshunov Andrey, Kool Marcel, Ellison David W
Abstract excerpt
Of nine ependymoma molecular groups detected by DNA methylation profiling, the posterior fossa type A (PFA) is most prevalent. We used DNA methylation profiling to look for further molecular heterogeneity among 675 PFA ependymomas. Two major subgroups, PFA-1 and PFA-2, and nine minor subtypes were discovered. Transcriptome profiling suggested a distinct histogenesis for PFA-1 and PFA-2, but their clinical...
Topics
- DNA Methylation
- Ependymoma
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- HEK293 Cells