Article
An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.
The Journal of pharmacology and experimental therapeutics - 1 Oct 2006
Borghese C M, Werner D F, Topf N, Baron N V, Henderson L A, Boehm S L, Blednov Y A, Saad A, Dai S, Pearce R A, Harris R A, Homanics G E, Harrison N L
Abstract excerpt
Volatile anesthetics and alcohols enhance transmission mediated by gamma-aminobutyric acid type A receptors (GABA(A)Rs) in the central nervous system, an effect that may underlie some of the behavioral actions of these agents. Substituting a critical serine residue within the GABA(A)R alpha(1) subunit at position 270 with the larger residue histidine eliminated receptor modulation by isoflurane, but it also...
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