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Article

Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.

The Journal of pharmacology and experimental therapeutics - 1 Feb 2012

Blednov Yuri A, Benavidez Jill M, Homanics Gregg E, Harris R Adron

Abstract excerpt

We used behavioral pharmacology to characterize heterozygous knockin mice with mutations (Q266I or M287L) in the α1 subunit of the glycine receptor (GlyR) (J Pharmacol Exp Ther 340:304-316, 2012). These mutations were designed to reduce (M287L) or eliminate (Q266I) ethanol potentiation of GlyR function. We asked which behavioral effects of ethanol would be reduced more in the Q266I mutant than the M287L and found...

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Identifiers

PMID: 22037202
DOI: 10.1124/jpet.111.185124
PMCID: PMC3263963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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