Article
Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2014
Aguayo Luis G, Castro Patricio, Mariqueo Trinidad, Muñoz Braulio, Xiong Wei, Zhang Li, Lovinger David M, Homanics Gregg E
Abstract excerpt
Alcohol abuse and alcoholism are major health problems and one of the leading preventable causes of death. Before achieving better treatments for alcoholism, it is necessary to understand the critical actions of alcohol on membrane proteins that regulate fundamental functions in the central nervous system. After generating a genetically modified knock-in (KI) mouse having a glycine receptor (GlyR) with...
Topics
- Animals
- Blotting, Western
- Brain Stem
- Cells, Cultured
- Ethanol
- Female
- Gene Knock-In Techniques
- Hypnotics and Sedatives
- Immunohistochemistry
- Male
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Transgenic