Article
Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.
Neuroscience letters - 13 Jan 2011
Harris R A, Osterndorff-Kahanek E, Ponomarev I, Homanics G E, Blednov Y A
Abstract excerpt
Knock-in mice were constructed with mutations in the α1 (H(270), A(277)) and α2 (H(270), A(277)) subunits of the GABAA receptor, which resulted in receptors that lacked modulation by ethanol but retained normal responses to GABA in vitro. A key question is whether these mutant receptors also func...
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