Article
Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice.
Genes, brain, and behavior - 1 Feb 2024
Plasil S L, Farris S P, Blednov Y, Mayfield R D, Mangieri R A, Nwokeji U J, Aziz H C, Lambeth P S, Harris R A, Homanics G E
Abstract excerpt
Chronic alcohol exposure results in widespread dysregulation of gene expression that contributes to the pathogenesis of Alcohol Use Disorder (AUD). Long noncoding RNAs are key regulators of the transcriptome that we hypothesize coordinate alcohol-induced transcriptome dysregulation and contribute to AUD. Based on RNA-Sequencing data of human prefrontal cortex, basolateral amygdala and nucleus accumbens of AUD...
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