Article

Structural Model of the Proline-rich Domain of Huntingtin exon-1 fibrils

2020-04-20

Abstract excerpt

Huntington’s disease (HD) is a heritable neurodegenerative disease that is caused by a CAG expansion in the first exon of the huntingtin gene. This expansion results in an elongated polyglutamine (polyQ) domain that increases the propensity of huntingtin exon-1 (HTTex1) to form cross-β fibrils. While the polyQ domain is important for fibril formation, the dynamic, C-terminal proline-rich domain (PRD) of HTTex1 mak...

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Literature Corpus work: 743f4d0c-0e5f-52fc-8c43-f480d46ef1e3
DOI: 10.1101/2020.04.17.046714

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