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Article

Yak Response to High-Altitude Hypoxic Stress by Altering mRNA Expression and DNA Methylation of Hypoxia-Inducible Factors

30 Apr 2015

Abstract excerpt

Hypoxia-inducible factors (HIFs) are oxygen-dependent transcriptional activators, which play crucial roles in tumor angiogenesis and mammalian development, and regulate the transcription of genes involved in oxygen homeostasis in response to hypoxia. However, information on HIF-1α and HIF-2α in yak (Bos grunniens) is scarce. The complete coding region of yak HIF-2α was cloned, its mRNA expression in several...

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PMID: 25927169
DOI: 10.1080/10495398.2014.1002563

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