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Article

Analysis of hypoxia-inducible factor alpha polyploidization reveals adaptation to Tibetan Plateau in the evolution of schizothoracine fish.

BMC evolutionary biology - 28 Aug 2014

Guan Lihong, Chi Wei, Xiao Wuhan, Chen Liangbiao, He Shunping

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor (HIF) is a master regulator that mediates major changes in gene expression under hypoxic conditions. Though HIF family has been identified in many organisms, little is known about this family in schizothoracine fish. RESULTS: Duplicated hif-α (hif-1αA, hif-1αB, hif-2αA, and hif-2αB) genes were identified in schizothoracine fish. All the deduced HIF-α proteins contain the main...

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Identifiers

PMID: 25205386
DOI: 10.1186/s12862-014-0192-1
PMCID: PMC4162920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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