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HIF-Dependent Mechanisms of Relationship between Hypoxia Tolerance and Tumor Development

3 Sept 2021

Abstract excerpt

Oxygen deficiency is one of the key pathogenetic factors determining development and severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of oxygen activates the signaling pathway of the hypoxia-inducible transcription factor HIF in cells that has three isoforms, HIF-1, HIF-2, HIF-3, regulating expression of several thousand genes. Throughout tumor progression, HIF activation...

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PMID: 34903150
DOI: 10.1134/s0006297921100011

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