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Article

Mutations in the Leucine Zipper-Like Motif of the Human Parainfluenza Virus 3 Fusion Protein Impair Fusion Activity.

Intervirology - 1 Jan 2015

Xie Wenyan, Wen Hongling, Chu Fulu, Yan Shaofeng, Xie Wenli, Lin Bin, Chen Yuzhen, Li Zhenmei, Ren Guijie, Song Yanyan, Zhao Li, Wang Zhiyu

Abstract excerpt

OBJECTIVE: To investigate the effect of the leucine zipper-like motif between HRA and HRB of the human parainfluenza virus 3 fusion protein on fusion activity. METHODS: Site-directed mutagenesis was utilized to substitute the heptadic residues at 257, 264, 271, 278, 285, 292, and 299 in this motif with alanine. Additionally, 3 middle heptadic leucine residues at 271, 278, and 285 were replaced with alanine singly...

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Identifiers

PMID: 26694747
DOI: 10.1159/000441978
PMCID: PMC7179560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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