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Article

Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach.

Oncotarget - 18 Jul 2017

Moran Bruce, Das Sudipto, Smeets Dominiek, Peutman Gillian, Klinger Rut, Fender Bozena, Connor Kate, Ebert Matthias, Gaiser Timo, Prehn Jochen Hm, Bacon Orna, Kay Elaine, Hennessy Bryan, Murphy Verena, Ylstra Bauke, Lambrechts Diether, Byrne Annette T, Gallagher William M, O'Connor Darran P

Abstract excerpt

DNA methylation is altered in many types of disease, including metastatic colorectal cancer. However, the methylome has not yet been fully described in archival formalin-fixed paraffin embedded (FFPE) samples in the context of matched fresh-frozen (FF) tumor material at base-pair resolution using a targeted approach. Using next-generation sequencing, we investigated three pairs of matched FFPE and FF samples to...

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Identifiers

PMID: 28611295
DOI: 10.18632/oncotarget.18296
PMCID: PMC5564631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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