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Article

Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

PloS one - 1 Jan 2018

Prentice Leah M, Miller Ruth R, Knaggs Jeff, Mazloomian Alborz, Aguirre Hernandez Rosalia, Franchini Patrick, Parsa Kourosh, Tessier-Cloutier Basile, Lapuk Anna, Huntsman David, Schaeffer David F, Sheffield Brandon S

Abstract excerpt

Genomic analysis of cancer tissues is an essential aspect of personalized oncology treatment. Though it has been suggested that formalin fixation of patient tissues may be suboptimal for molecular studies, this tissue processing approach remains the industry standard. Therefore clinical molecular laboratories must be able to work with formalin fixed, paraffin embedded (FFPE) material. This study examines the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29698444
DOI: 10.1371/journal.pone.0196434
PMCID: PMC5919577

Genes

UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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