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Article

Association of RASgrf1 methylation with epileptic seizures.

Oncotarget - 11 Jul 2017

Chen Xiaoni, Peng Xi, Wang Liang, Fu Xinwei, Zhou Ji Xiu, Zhu Binglin, Luo Jing, Wang Xuefeng, Xiao Zheng

Abstract excerpt

DNA methylation, one of the mechanisms of epigenetic regulation, has been suggested to be related with epilepsy. RASgrf1 is a paternally imprinted gene and has a differentially methylated region (DMR) at the promoter that can silence gene expression. We have previously observed the down-regulation of RASgrf1 in the temporal neocortex of epilepsy patients and in the hippocampus of epileptic animals. Here, we...

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Identifiers

PMID: 28611277
DOI: 10.18632/oncotarget.18000
PMCID: PMC5542267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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