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Sarcosine Remodels DNA Methylation-Linked Transcriptional Networks During Epileptogenesis in the Rat Kindling Model

2026-07-13

Abstract excerpt

DNA methylation is a key regulator of epileptogenesis. Sarcosine, a glycine transporter 1 (GlyT1) inhibitor and methyl donor, suppresses kindling-induced epileptogenesis and alters hippocampal DNA methylation, but its locus-specific epigenetic effects remain poorly understood. Here, reduced representation bisulfite sequencing (RRBS) was combined with targeted gene expression analysis in the hippocampus of sarcosin...

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Literature Corpus work
e9b41311-afcc-5435-bc6a-6aa25e04c290
DOI
10.20944/preprints202607.0837.v1
Open publication

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Sarcosine Remodels DNA Methylation-Linked Transcriptional Networks During Epileptogenesis in the Rat Kindling ModelDOI 10.20944/preprints202607.0837.v1
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