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Article

DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures

19 Aug 2019

Abstract excerpt

BACKGROUND: Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) is a common pharmaco-resistant epilepsy referred for adult epilepsy surgery. Though associated with prolonged febrile seizures (FS) in childhood, the neurobiological basis for this relationship is not fully understood and currently no preventive or curative therapies are available. DNA methylation, an epigenetic mechanism catalyzed by DNA...

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PMID: 31426844
DOI: 10.1186/s13148-019-0721-2

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